queries regarding local erythropoietin injection in tibiofibular fracture healing

Queries Regarding Local Erythropoietin Injection in Tibiofibular Fracture Healing

We would like to congratulate Dr. Bakhshi and colleagues for being the first group to publish scientific evidence regarding the osteogenic effect of erythropoietin (EPO) in a clinical trial (1). As you correctly report, several preclinical studies have shown the efficacy of Erythropoietin to increase bone healing at early time points (2-4).In agreement with your approach, we strongly believe th...

Local Erythropoietin Injection in Tibiofibular Fracture Healing

BACKGROUND Erythropoietin (EPO), in addition to its function as an erythropoiesis regulator has a regenerative activity on some nonhematopoietic tissues. Animal studies have suggested a role for erythropoietin in bone healing. OBJECTIVES The present study aimed to evaluate the effects of local EPO injection in healing of tibiofibular fractures. MATERIALS AND METHODS In a prospective double ...

in reply to: queries regarding local erythropoietin injection in tibiofibular fracture healing

local erythropoietin injection in tibiofibular fracture healing

conclusions epo injection into the site of tibiofibular fractures may possibly accelerate healing. background erythropoietin (epo), in addition to its function as an erythropoiesis regulator has a regenerative activity on some nonhematopoietic tissues. animal studies have suggested a role for erythropoietin in bone healing. objectives the present study aimed to evaluate the effects of local epo...

In Reply to: Queries Regarding Local Erythropoietin Injection in Tibiofibular Fracture Healing

In replyWe would like to thank Dr. Duedal Rölfing for his keen observations. We hope that this study encourages prospective scientific publications. Erythropoietin (EPO) is a glycoprotein produced by the kidney which promotes the formation of red blood cells in the bone marrow. Recent studies have determined additional roles of EPO in tissue survival and cellular proliferation (1-3). EPO may ac...

Effects of erythropoietin on fracture healing in rats.

F healing and the factors affecting it has always attracted researchers’ curiosity. Fracture healing is a complex process, local (mechanical, physical, chemical, environmental), and systemic (hormonal factors, vitamins, drugs, systemic growth factors, diseases) factors all play a part at each stage. Although the histopathological process of fracture healing is now almost completely understood, ...